Genetic architecture of subcortical brain regions: common and region-specific genetic contributions
نویسندگان
چکیده
منابع مشابه
Genetic architecture of subcortical brain regions: common and region-specific genetic contributions.
Understanding the aetiology of patterns of variation within and covariation across brain regions is key to advancing our understanding of the functional, anatomical and developmental networks of the brain. Here we applied multivariate twin modelling and principal component analysis (PCA) to investigate the genetic architecture of the size of seven subcortical regions (caudate nucleus, thalamus,...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences1. Subcortical brain regions form circuits with cortical areas to coordinate movement2, learning, memory3 and motivation4, and altered circuits can lead to abnormal behaviour and disease2. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide asso...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
متن کاملCommon genetic variants influence human subcortical brain structures
The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour anddisease. To investigate how commongenetic variants affect the structure of thesebrain regions, herewe conduct genome-wide association s...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2014
ISSN: 1601-1848
DOI: 10.1111/gbb.12177